GSTs are involved in the main detoxification route of AFB1- exo -8,9-epoxide by catalyzing the conjugation of AFB1- exo -8,9-epoxide to endogenous GSH
While that's substantially higher than the 600mg starting dose we generally favor for people new to NAC, it reflects the GlyNAC protocols studied in healthy-aging research.34 57 58 Some readers may prefer to start with a smaller serving for tolerability, but the clinical research on GlyNAC has generally evaluated gram-level doses of both ingredients, so it's unclear whether substantially lower amounts would provide the same benefits
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Although glutathione can regenerate itself (through the enzyme glutathione reductase), it isnt unlimited and can be depleted